Ok so sometimes you might run into an issue where either the System Attendant or the AD Topology or both services will not start. Typically this can be caused by 1 of 2 reasons:
A. The server is being disallowed from accessing AD
B. The server cannot reach AD
Here's a list of the most common fixes:
1. Verify your DNS records for Exchange, and DC's
2. Disable any firewalls on your Global Catalog server
make sure your Sites in AD are configured correctly and that the sites can talk to each other
3. check to make sure the security groups Exchange Domain Servers and Exchange Enterprise Servers still exist in ADUC
4. Verify the server hosting your GC is up and accessible
5. Ping your GC from Exchange
6. Make sure AD replication is working correctly
7. Make sure the NTFS perms on the Exchange folder on your Exchange server is still set to allow full access to System and Administrators
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